Pancreatic NMDA receptors as possible drug targets. In contrast to NMDA receptors in the nervous system, the role of NMDA receptors in pancreatic islets and the insulin-secreting beta cells is less known. Data presented in the April issue of Nature Medicine bring new understanding of the cell processes involved in type 2 diabetes mellitus and …
Proteomic Analysis reveals involvement of the FPR2 pathway in insulin resistance Elevated levels of the free fatty acid palmitate are found in the plasma of obese patients and induce insulin resistance. In a study presented in the April issue of Molecular & Cellular Proteomics, the skeletal muscle secretome in response to palmitate-induced insulin resistance was …
Voltage-gated CaV channels as potential targets for anti-diabetes therapy The voltage-gated Ca(2+) (CaV) channel acts as a key player in β cell physiology and pathophysiology. β cell CaV channels undergo hyperactivation subsequent to exposure to type 1 diabetic (T1D) serum resulting in Ca(2+)-triggered β cell apoptosis. In the March 2015 issue of Cellular and Molecular …
Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice Endogenous expression of tailored nanoparticles in cells followed by application of low-frequency radio waves or a magnetic field can be used to noninvasively modulate gene expression. This approach successfully induces insulin transgene expression in diabetic mice. Read more: Regulation of glucose homeostasis using radiogenetics and …
The results from new findings about the molecular mechanisms behind the age-dependent deterioration in β-cell function have been published in Advances in Biological Regulation (formerly Advances in Enzyme Regulation); a journal reporting cutting edge scientific progress on regulation at the molecular level. Defects in pancreatic β-cell function and survival are key components in type 2 diabetes. …
Young capillary vessels rejuvenate aged pancreatic islets. A recent study published in the journal PNAS shows that young capillary vessels rejuvenate aged pancreatic islets. This finding challenges the common view that pancreatic beta-cells become inefficient with age. The reduction of insulin production within the cells may instead be affected by systemic aging factors. Read more: Press release …
Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents. In a study, presented in Nature Communications, we investigated the role of primary cilia in islet function and glucose homeostasis. This is possibly the first study to address the role of primary cilia in glucose handling, insulin signalling and T2DM …
T Cells behaviors uncovered with InSight Technology featured in JEM on the 24th of February, 2014. How real-time imaging studies depicted the interaction of self-antigen-specific T cells with target tissue cells in vivo, has been described in an article in JEM, The Journal of Experimental Medicine. The study illustrates tolerance induction by contact-based immune cell …
Science Daily reports on InSight Technology on the 29th of January, 2014. The website Science Daily reports on how the InSight Technology has been applied to the studying of the inflammatory process that occurs in the pancreas during type 1 diabetes. Unlike other non-invasive techniques such as PET and MRI, the InSight technology enables in …
Images of the researchers in Professor Per-Olof Berggren’s group were presented an Biomedical Picture of the Day (BPoD) on the 31st of December 2013. BPoD stands for Biomedical Picture of the Day. The website is managed by the MRC Clinical Sciences Centre. It aims to engage everyone in the wonders of biomedicine. Images are provided by the …