The body’s “glucostat” identified On the web-site of Karolinska Institutet, there is a recent post regarding a new findings, published in the scientific journal Cell Metabolism; “It is the pancreatic islets that have the overall responsibility for maintaining normal blood glucose levels in our bodies, according to a new study by researchers at Karolinska Institutet …
Pancreatic islet blood flow dynamics in primates On the web-site of Karolinska Institutet, there is recent post regarding a new publication in the scientific journal Cell Reports. “Researchers have established a unique method enabling them to study the function of insulin-producing cells under conditions that are similar to those in humans. This can pave the way …
Per-Olof Berggren has been elected to The National Academy of Medicine The National Academy of Medicine announced today the election of 70 U.S. members and 9 international members during its annual meeting. Election to the Academy is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have …
New non-invasive method for studying the development of insulin-producing cells On the web-site of Karolinska Institutet, there is recent post regarding a new publication: “Researchers at Karolinska Institutet and Nanyang Technological University in Singapore have produced a unique method for monitoring the development of insulin-producing cells, which play a key part in regulating blood glucose …
Insulin-secreting cells report on insulin resistance On the web-site of Karolinska Institutet, there is a recent post (see “Research news”) regarding a new publication: “Diabetes researchers at Karolinska Institutet have developed a novel technique that makes it possible to monitor insulin resistance in a non-invasive manner over time in mice. The new method, presented in …
Liraglutide compromises pancreatic beta cell function in a humanized mouse model On the web-site of Karolinska Institutet, there is a recent post regarding a new publication of high impact: “Long-term use of liraglutide, a substance that helps to lower blood sugar levels in patients with type 2 diabetes, can have a deteriorating effect on insulin-producing …
Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets. Insulin secretion plays a central role in glucose homeostasis and diabetes. However, all aspects of the macroscopic secretory pattern at the cellular level are not totally clear. The results from a study presented in the December 2015 issue of Diabetologia, reveal how …
New insights into the architecture of the islet of Langerhans: a focused cross-species assessment. Many studies on human islet cells rely on the legacy of rodent-based investigations. Since islet physiology and pathology may differ between rodents and humans, the current knowledge of interspecies islet cell cytoarchitecture and its potential impact on islet function is reviewed …
PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation. Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin. A remaining question is how an insulin target cell/tissue can be insulin resistant in one biological function and insulin sensitive in another at …
Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase. A study presented in the September issue of Cellular Signalling, suggests that apolipoprotein a1 can alleviate obesity related metabolic disease by inducing AMPK dependent mitochondrial biogenesis. Read more: Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase. Parkyong Song, Yonghoon Kwon, Kyungmoo Yea, Hyo-Youl Moon, …