New insights into the architecture of the islet of Langerhans: a focused cross-species assessment. Many studies on human islet cells rely on the legacy of rodent-based investigations. Since islet physiology and pathology may differ between rodents and humans, the current knowledge of interspecies islet cell cytoarchitecture and its potential impact on islet function is reviewed …

PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation. Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin. A remaining question is how an insulin target cell/tissue can be insulin resistant in one biological function and insulin sensitive in another at …