The exact cause of either type 1 or type 2 diabetes still remains unknown. Inflammation of the insulin-producing islets of Langerhans seems to be one of the common denominators during the early stage of both diseases. InSight Technology is a promising analytical tool for studying the inflammation processes. The review is published in Diabetes, Obesity …
Signal transduction between the diabetogenic blood factor apolipoprotein CIII (apoCIII) and insulin-producing beta cells is now clarified. ApoCIII acts upon the calcium channels through kinases PKA and Src, involving a receptor SR-BI and an integrin beta1. The results are published in Cellular and Molecular Life Sciences on the 15th of August 2013. Calcium is very …
Advantages of and protocols for using InSight Technology as an imaging platform are presented in the March 2013 issue of the Journal of Visualized Experiments. Intravital, performed in the living organism, imaging has become an important tool in life sciences. A number of different technologies have emerged over the years and have been adapted to …
Researchers in Professor P-O Berggren’s group proposed utilizing InSight Technology to answer questions of islet development during infancy and puberty and to describe a ”point-of-no-return” for islet development programming. The commentary is published in Molecular Metabolism in January 2013. Genes and obesity are two major factors that contribute to the development of type 2 diabetes …
Professor Per-Olof Berggren has received 4 major distinctions during 2012: Alex Hirsch from Karolinska Institutet, Wallenberg Scholars, The Novo Nordisk Foundation Advanced Grant and Kroc Lecture at Boston University Medical Center. Professor Berggren’s distinctions are for the following achievements: Axel Hirsch Prize from Karolinska Institutet. The prize is for scientific achievements, which are potentially of major significance to the treatment of …
Blood glucose levels are controlled by the autonomous nervous system. Parasympathetic axons directly influence islet function, leading to higher insulin release and lower levels of blood glucose. The results are published in December 2012 in PNAS. The autonomous nervous system responsible for the unconscious regulation consists of parasympathetic and sympathetic parts, managing the calm and …
Once a hormone is released it can stimulate its own production. This principle was previously proven by Professor Berggren’s group in relation to insulin. Now the same group shows the generality of the approach: glucagon secreting cells increase their production when they sense increasing levels of glucagon. The results are published in PNAS in December …
Biocrine’s CEO Professor PO Berggren was interviewed by NyTeknik, Swedish leading technology and IT newspaper. Treating diabetes with transplanted insulin-producing islets of Langerhans was the main subject of the discussion. Transplantation into the eye is a novel method developed by Prof Berggren’s research group. So far, the procedure has been thoroughly tested in mice leading …
The researchers in Professor Berggren’s group are in the forefront of resolving key challenges in understanding the molecular signalling in the islets of Langerhans, the endocrine pancreas. Specification of differences between human and mouse islet architecture and function as well as possibility to image molecular processes in the living organism will eventually lead to insights …
Inositides are involved in regulating the insulin release from the pancreatic beta cell. New findings are published in Advances in Biological Regulation in September 2012. Inositides take an active part in regulating many vital processes in all cells in the organism. Depending on its primary function, cells have a specific footprint of what inositides they …