Professor Berggren’s research publications

Professor P-O Berggren and his research groups run an impressive list of scientific projects outside those commercialized by Biocrine. The research groups also participate in projects conducted by other groups. In most cases, all these projects result in successful scientific publications. 

Here is a list of publications generated since 2013:

  • Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells. SS Rajasekaran, J Kim, G-C Gaboardi, J Gromada, SB Shears, K Tiago dos Santos, El Nolasco, S de Souza Ferreira, C Illies, M Köhler, C Gu, SH Ryu, JO Martins, E Darré, CJ Barker, P-O Berggren. Cellular Signalling 46: 120-128, 2018.
  • Paracrine interactions within the pancreatic islet determine the glycemic set point. R Rodriguez Diaz, RD Molano JR Weitz, MH Abdulreda, DM Berman-Weinberg, B Leibiger, I Leibiger, NS Kenyon, C Ricordi, A Pileggi, P-O Berggren. Cell Metab, 27: 549-558, 2018.
  • Kynurenic acid and GPR35 regulate adipose tissue energy homeostasis and inflammation. LZ Agudelo, DMS Ferreira, I Cervenka, G Bryzgalova, S Dadvar, PR Jannig, AT Pettersson-Klein, T Lakshmikanth, EG Sustarsic, M Porsmyr-Palmertz, JC Correia, M Izadi, V Martinez-Redondo, PM Ueland, Ö Midttun, Z Gerhart-Hines, P Brodin, T Pereira, P-O Berggren, JL Ruas. Cell Metab 27: 378-394, 2018.
  • Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity. SS Rajasekaran, C Illies, SB Shears, H Wang, TS Ayla, JO Martins, E Daré, P-O Berggren & CJ Barker. Cellular Signalling 42:127-133, 2018.
  • Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways. H Jeong, A Koh, J Lee, D Park, JO Lee, MN Lee, K-J Jo, HNK Tran, E Kim, B-S Min, HS Kim, P-O Berggren, SH Ryu. Scientific Report DOI:10.1038/s41598-017-18081-8, 2017.
  • Mechanistic understanding of insulin receptor modulation: Implications for the development of anti-diabetic drugs. N-O Yunn, J Kim, Y Kim, I Leibiger, P-O Berggren, SH Ryu. Pharmacology and Therapeutics doi:10.1016/j. pharmathera.2017.12.005
  • DISC1 modulates neuronal stress responses by gate-keeping ER-mitochondria Ca2+ transfer through the MAM. SJ Park, SB Lee, Y Suh, S-J Kim, N Lee, J-H Hong, C Park, Y Woo, K Ishizuka, J-H Kim, P-O Berggren, A Sawa, SK Park. Cell Reports 21:2748-2759, 2017.
  • Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes, PP van Krieken, A Dicker, M Eriksson, PL Herrera, U Ahlgren, P-O Berggren & E Ilegems. Scientific Reports DOI:10.1038/s41598-017-12124.w, 2017.
  • Insulin modulates the frequency of Ca2+ oscillations in mouse pancreatic islets. B Lee, T Song, K Lee, J Kim, P-O Berggren, SH Ry & J Jo. PLoS ONE doi.org/10.1371/journal.pone.0183569, 2017
  • SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+ oscillations in β cell networks. T Daraio, LK Bombek, M Gosak, I Valladolid-Acebes, MS Klemen, E Refai, P-O Berggren, K Brismar, MS Rupnik & C Bark. Scientific Reports DOI:10.1038/s41598.017-08082-y.
  • Pancreatic islet blood flow dynamics in primates. JA Diez, R Arrojo E Drigo, X Zheng, GJ Augustine, VA Barathi, P-O Berggren. Cell Reports 20: 1490-1501, 2017.
  • Biochemical profiling of diabetes disease progression by multivariate vibrational microspectroscopy of the pancreas. C Nord, M Eriksson, A Dicker, A Eriksson, E Grong, E Ilegems, R Mårvik, B Kulseng, P-O Berggren, A Gorzsas, U Ahlgren. Scientific Reports DOI:10.1038/ s41598-017-0705-z, 2017.
  • Intraocular in vivo imaging of pancreatic islet cell physiology/pathology. I B Leibiger, P-O Berggren. Molecular Metabolism doi.org/10.1016/ j.molmet.2017.03.014.
  • The yin and yang of apolipoprotein CIII. K ÅvallL, P-O Berggren, L Juntti-Breggren. Diabetes Metab. http://dx.doi.org/10.1016/j.diabet.2017.03.009.
  • A novel toolbox to investigate tissue spatial organization applied to the study of the islets of Langerhans. Tnh Tran R Drigo, P-O Berggren, T Boudier. Scientific Report DOI: 10.1038/srep44261, 2017.
  • Preservation of anti-cancer and immunosuppressive properties of rapamycin achieved through controlled releasing particles. SCJ Loo, YL Fan, HW Wei, HM Tay, WM Guo, P-O Berggren. AAPS PharmaSciTech DOI: 10.1208/s12249-017-0745-x, 2017.
  • Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization. B Lee, T Song, K Lee, J Kim, S Han, P-O Berggren, SH Ryu, J Jo. PLoS ONE DOI:10.1371/journal.pone.0172901, 2017.
  • Apolipoprotein CIII is a new player in diabetes. L Juntti-Berggren, P-O Berggren. Curr Opin Lipidol 28: 27-31, 2017.
  • 17β-estradiol suppresses visceral adipogenesis and activates brown adipose tissue-specific gene expression. SM Al-Qahtani, G Bryzgalova, I Valladolid-Acebes, M Korach-André, K Dahlman-Wright, S Efendic, P-O Berggren, N Portwood. Horm Mol Biol Clin Invest DOI 10.1515/hmbci-2016-0031
  • Human beta cells produce and release serotonin to inhibit glucagon secretion from alpha cells. J Almaca, J Molina, D Menegaz, AN Pronin, A Tamayo, V Slepak, P-O Berggren, A Caicedo. Cell Reports 17: 3281-3291, 2016.
  • Activation of hepatic AMPK by 17β-estradiol suppresses both nuclear receptor Nr2c2/TR4 and its downstream lipogenic targets, reduces gluconeogenic genes and improves insulin signaling. SM Al-Qahtani, G Bryzgalova, S Efendic, P-O Berggren, N Portwood. Dis Mol Med 4: 55-67, 2016
  • The different faces of the pancratic islet. MH Abdulreda, R Rodriguez-Dias, O Cabrera, A Caicedo, P-O Berggren. In: Pancreatic Islet Isolation (ed. M. Ramírez-Domínguez). Advances in Experimental Medicine and Biology 938: 11-24, 2016.
  • Clinical intraocular islet transplantation is not a number issue. A Shishido, A Caicedo, R Rodriguez-Diaz, A Pileggi, P-O Berggren, MH Abdulreda. CellR4 4(4): e2120, 2016.
  • Diabetes prevention through antiviral treatment in biobreeding rats. B Niklasson, G Arbrandt, A Kawecki, L Juntti-Berggren, P-O Berggren, Smal-Qahtani, A-L Gustafsson, G Bryzgalova, W Klitz. Viral Immunology DOI: 10.1089/vim.2016.0063, 2016.
  • The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibation. II Zaitseva, SV Zaitsev, P-O Berggren. Investigational New Drugs 34: 522-529, 2016.
  • Nephrin contributes to insulin secretion and affects mammalian target of rapamycin signaling independently of insulin receptor. R Villarreal, A Mitrofanova, D Maiguel, X Morales, J Jeon, F Grahammer, IB Leibiger, J Guzman, A Fachado, TH Yoo, A Busher Katin, J Gellermann, S Merscher, GW Burke, P-O Berggren, J Oh, TB Humber, A Fornoni. Journal of the American Society of Nephrology 27: 1029-1041, 2016
  • Silk matrices promote formation of insulin-secreting islet-like clusters. N Dekki Shalaly, M Ria, U Johansson, K Åvall, P-O Berggren, M Hedhammar. Biomaterials 90: 50-61, 2016.
  • Insulinotropic compounds decrease endothelial cell survival. II Zaitseva, P-O Berggren, SV Zaitsev. Toxicology in Vitro 33: 1-8, 2016.
  • The anterior chamber of the eye is a transplantation site that supports and enables visualization of beta cell development in mice. Y Ali, J Diez, L Selander, X Zheng, H Edlund & P-O Berggren. Diabetologia DOI 10.1007/s00125-016-3883-x, 2016.
  • Non-invasive cell type selective in vivo monitoring of insulin resistance dynamics. M Paschen, T Moede, B Leibiger, S Jacob, G Bryzgalova, IB Leibiger, P-O Berggren. Scientific Reports 6, article no 21448, 2016.
  • Liraglutide compromises pancreatic beta cell function in a humanized mouse model. Midhat H. Abdulreda, Rayner Rodriguez-Diaz, Alejandro Caicedo, Per-Olof Berggren. Cell Metabolism, online11 February 2016.
  • TLR3-/4-priming differentially promote Ca2+ signaling and cytokine expression and Ca2+ dependently augment cytokine release in hMSCs. KS Park, SH Kim, S-N Yang, KH Jung, MK Kim, P-O Berggren, HJ Kim & YG Chai. Scientific Reports, in press 2016.
  • ARA290 improves insulin release and glucose tolerance in type 2 diabetic GK rats. C Muller, K Y Assin, L-S Li, M Palmblad, S Efendic, P-O Berggren, A Cerami, M Brines, C-G Östenson. Mol Med doi: 10.21119/molmed.2015.00267.
  • Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets. J Almaca, T Liang, Hy Gaisano, HG Nam, P-O Berggren, A Caicedo. Diabetologia 58: 2810-2818, 2015.
  • Glucose intolerance and pancreatic β-cell dysfunction in the anorectic anx/anx mouse. C Lindfors, A Katz, L Selander, JE Johansen, G Marconi, M Schalling, T Hökfelt, P-O Berggren, S Zaitsev & IAK Nilsson. Am J Physiol Endocrinol Metab 309: E418-E427, 2015.
  • PI3K-C2α knockdown results in re-routing of insulin signaling and pancreatic beta cell proliferation. B Leibiger, T Moede, M Paschen, N-O Yunn, JH Lim, SH Ryu, T Pereira, P-O Berggren & IB Leibiger. Cell Reports 13: 15-22, 2015.
  • Outer hair cell lateral wall structure constrains the mobility of plasma membrane proteins. T Yamashita, A Hassan, S Jacob, J Temirov, R Gursky, L Horner, S Laijon, V Frohlich, P-O Berggren, WE Brownwell, M Auer, B Leibiger, M Melldo-Lagarde, J Fang, S Fras+E, A Fridberger, P Hakizimana, S Emasist & Zuo. PLOS Genetics DOI:10:1371/journal.pgen.1005500,2015.
  • New insights into the architecture of the islet of Langerhans: a focused cross-species assessment. R Arrojo E Drigo, Y Ali, J Diez, DK Srinivasan, P-O Berggren & Bo Boehm. Diabetologia 58: 2218-2228, 2015.
  • Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation. N-O Yunn, A Koh, S Han, JH Lim, S Park, J Lee, E Kim, SK Jang, P-O Berggren & SH Ruy. Nucleic Acids Research 43: 7688-7701, 2015.
  • Nephrin contributes to insulin secrection and affects mammalian target of rapamycin signaling independently of insulin receptor. R Villarreal, A Mitrofanova, D Maiguel, X Morales, J Jeon, F Grahammer, IB Leibiger, J Guzman, A Fachado, TH Yoo, A Buscher Katin, J Gellerman, S Merscher, GW Burke, P-O Berggren, J Oh, TB Huber & A Fornoni. J Am Soc Nephrol 27: 2015, doi: 10.1681/ASN.2015020210.
  • Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase. P Song, Y Kwon, K Yea, H-Y Moon, JH Yoon, J Ghim, H Hyun, D Kim, A Koh, P-O Berggren, P-G Suh & SH Ryu. Cellular Signalling 27: 1873-1881, 2015.
  • Pancreatic islet survival and engraftment is promoted by culture on functionalized spider silk matrices. U Johansson, M Ria, K Åvall, N Dekki Shalaly, SV Zaitsev, P-O Berggren & M Hedhammar. PLoS One DOI:20.1371/journal.pone.0130169, 2015.
  • Secretome protein signature of human gastrointestinal stromal tumor cells. E Berglund, E Daré, RMM Branca, P Akcakaya, R Fröbom, P-O Berggren, W-O Lui, C Larsson, J Zedenius, L Orre, J Lehtiö, J Kim & R Bränström. Exp Cell Res 336: 158-170, 2015.
  • The pancreatic β-cell in deadly encounter with apolipoprotein CIII. L Juntti-Berggren, Y Ali & P-O Berggren. Cell Cycle 14: 1-2, 2015.
  • Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion. E Ilegems, PP Van Krieken, PK Edlund, A Dicker, T Alanentalo, M Eriksson, S Mandic, U Ahlgren & P-O Berggren. Scientific Reports DOI: 10.1038/srep10740, 2015.
  • Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes. K Åvall, Y Ali, IB Leibiger, B Leibiger, T Moede, M Paschen, A Dicker, E Daré, M Köhler, E Ilegems, MH Abdulreda, M Graham, RM Crooke, VSY Tay, E Refai, SK Nilsson, S Jacob, L Selander, P-O Berggren & L Juntti-Berggren. Proc Natl AcadSci USA 112: E2611-E2619, 2015.
  • Proteomic analysis of the palmitate-induced myotube secretome reveals involvement of the annexin A1-FPR2 pathway in insulin resistance. J H Yoon, D Kim, J-H Jang, J Ghim, S Park, P Song, Y Kwon, J Kim, D Hwang, Y-S Bae, P-G Suh, P-O Berggren & SH Ryu. Mol Cell Proteomics 14: 882-892, 2015.
  • Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. J Marquard, S Otter, A Welters, A Stirban, A Fischer, J Eglinger, D Herebian, O Kletke, MS Klemen, A Stozer, S Wnendt, L Piemonti, M Köhler, J Ferrer, B Thoens, F Schliess, MS Rupnik, T Heise, P-O Berggren, N Klöcker, T Meissner, E Mayatepek, D Eberhard, M Kragl & E Lammert. Nature Medicine 21: 363-372, 2015.
  • Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice. IB Leibiger & P-O Berggren. Nature Medicine 21: 14-16, 2015.
  • β-cell Ca2+ dynamics and function are compromised in aging. CJ Barker, L Li, M Köhler & P-O Berggren. Advances in Biological Regulation 57: 112-119, 2015.
  • Cav1.2 and Cav1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum. G Yang, Y Shi, J Yu, Y Li, L Yu, A Welling, F Hofmann, J Striessnig, L Juntti-Berggren, P-O Berggren & S-N Yang. Cell Mol Life Sci 72: 1197-1207, 2015.
  • Young capillary vessels rejuvenate aged pancreatic islets. Almaça J, Molina J, Arrojo E Drigo R, Abdulreda MH, Jeon WB, Berggren PO, Caicedo A, Nam HG. Proc Natl Acad Sci USA. 111: 17612-17617, 2014.
  • Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents. Gerdes JM, Christou-Savina S, Xiong Y, Moede T, Moruzzi N, Karlsson-Edlund P, Leibiger B, Leibiger IB, Ostenson CG, Beales PL, Berggren PO. Nat Commun. 2014 Nov 6;5:5308.
  • Intravital imaging of cytotoxic T lymphocytes. Faleo G, Berggren PO, Pileggi A. Methods Mol Biol. 2014;1186:121-9.
  • Ionic mechanisms in pancreatic β cell signaling. Yang SN, Shi Y, Yang G, Li Y, Yu J, Berggren PO. Cell Mol Life Sci. 2014 Nov;71(21):4149-77.
  • Expression of nucleobindin 1 (NUCB1) in pancreatic islets and other endocrine tissues. Williams P, Tulke S, Ilegems E, Berggren PO, Broberger C. Cell Tissue Res. 2014 Nov;358(2):331-42.
  • CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum. Yang G, Shi Y, Yu J, Li Y, Yu L, Welling A, Hofmann F, Striessnig J, Juntti-Berggren L, Berggren PO, Yang SN. Cell Mol Life Sci. 2014 Oct 8.
  • Control of insulin secretion by cholinergic signaling in the human pancreatic islet. Molina J, Rodriguez-Diaz R, Fachado A, Jacques-Silva MC, Berggren PO, Caicedo A. Diabetes. 2014 Aug;63(8):2714-26.
  • Short and prolonged exposure to hyperglycaemia in human fibroblasts and endothelial cells: metabolic and osmotic effects. Moruzzi N, Del Sole M, Fato R, Gerdes JM, Berggren PO, Bergamini C, Brismar K. Int J Biochem Cell Biol. 2014 Aug;53:66-76.
  • Mitochondrial GTP insensitivity contributes to hypoglycemia in Hyperinsulinemia Hyperammonemia (HI/HA) by inhibiting glucagon release. Kibbey RG, Choi CS, Lee HY, Cabrera O, Pongratz RL, Zhao X, Birkenfeld AL, Li C, Berggren PO, Stanley C, Shulman GI. Diabetes. 2014 Jul 14.
  • CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Kim D1, Kim J, Yoon JH, Ghim J, Yea K, Song P, Park S, Lee A, Hong CP, Jang MS, Kwon Y, Park S, Jang MH, Berggren PO, Suh PG, Ryu SH. Diabetologia. 2014 Jul;57(7):1456-65.
  • Adipsin is an adipokine that improves β cell function in diabetes. Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM. Cell. 2014 Jul 3;158(1):41-53.
  • Defects in β-Cell Ca2+ Dynamics in Age-Induced Diabetes. Li L, Trifunovic A, Köhler M, Wang Y, Berglund JP, Illies C, Juntti-Berggren L, Larsson NG, Berggren PO. Diabetes. 2014 Jul 1.
  • Contribution of endothelial injury and inflammation in early phase to vein graft failure: the causal factors impact on the development of intimal hyperplasia in murine models. Tseng CN, Karlöf E, Chang YT, Lengquist M, Rotzius P, Berggren PO, Hedin U, Eriksson EE. PLoS One. 2014 Jun 2;9(6):e98904.
  • Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance. Miska J, Abdulreda M, Devarajan P, Bon Lui J, Suzuki J, Pileggi A, Berggren PO, Chen Z. The Journal of Experimental Medicine. 2014 Feb 24.
  • In vivo imaging of kidney glomeruli transplanted into the anterior chamber of the mouse eye. Kistler AD, Caicedo A, Abdulreda MH, Faul C, Kerjaschki D, Berggren PO, Reiser J, Fornoni A. Sci Rep. 2014 Jan 27;4:3872
  • aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra. Antonson P, Matic M, Portwood N, Kuiper RV3, Bryzgalova G, Gao H, Windahl SH, Humire P, Ohlsson C, Berggren PO, Gustafsson JÅ, Dahlman-Wright K. PLoS One. 2014 Jan 8;9(1)
  • Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands. Wu H, Mezghenna K, Marmol P, Guo T, Moliner A, Yang SN, Berggren PO, Ibáñez CF. Diabetologia. 2013 Oct 17.
  • TNF-α and IFN-γ promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration. Jaczewska J, Abdulreda MH, Yau CY, Schmitt MM, Schubert I, Berggren PO, Weber C, Koenen RR, Moy VT, Wojcikiewicz EP. J Leukoc Biol. 2013 Sep 26
  • Imaging dynamics of CD11c(+) cells and Foxp3 (+) cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes. Schmidt-Christensen A, Hansen L, Ilegems E, Fransén-Pettersson N, Dahl U, Gupta S, Larefalk A, Hannibal TD, Schulz A, Berggren PO, Holmberg D. Diabetologia. 2013 Dec;56(12):2669-78.
  • Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic β-cells. Park SH, Ryu SY, Yu WJ, Han YE, Ji YS, Oh K, Sohn JW, Lim A, Jeon JP, Lee H, Lee KH, Lee SH, Berggren PO, Jeon JH, Ho WK. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12673-8
  • Role of T cell recruitment and chemokine-regulated intra-graft T cell motility patterns in corneal allograft rejection. Tan Y, Abdulreda MH, Cruz-Guilloty F, Cutrufello N, Shishido A, Martinez RE, Duffort S, Xia X, Echegaray-Mendez J, Levy RB, Berggren PO, Perez VL. Am J Transplant. 2013 Jun;13(6):1461-73.
  • Evidence for Ca(2+)-regulated ATP release in gastrointestinal stromal tumors. Berglund E, Berglund D, Akcakaya P, Ghaderi M, Daré E, Berggren PO, Köhler M, Aspinwall CA, Lui WO, Zedenius J, Larsson C, Bränström R. Exp Cell Res. 2013 May 1;319(8):1229-38.
  • Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action. Matic M, Bryzgalova G, Gao H, Antonson P, Humire P, Omoto Y, Portwood N, Pramfalk C, Efendic S, Berggren PO, Gustafsson JÅ, Dahlman-Wright K. PLoS One. 2013;8(2):e57458
  • C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy. Koh A, Lee MN, Yang YR, Jeong H, Ghim J, Noh J, Kim J, Ryu D, Park S, Song P, Koo SH, Leslie NR, Berggren PO, Choi JH, Suh PG, Ryu SH. Mol Cell Biol. 2013 Apr;33(8):1608-20
  • Emodin regulates glucose utilization by activating AMP-activated protein kinase. Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH. J Biol Chem. 2013 Feb 22;288(8):5732-42.
  • Localization of cholesterol, amyloid and glia in Alzheimer’s disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging. Solé-Domènech S, Sjövall P, Vukojević V, Fernando R, Codita A, Salve S, Bogdanović N, Mohammed AH, Hammarström P, Nilsson KP, LaFerla FM, Jacob S, Berggren PO, Giménez-Llort L, Schalling M, Terenius L, Johansson B. Acta Neuropathol. 2013 Jan;125(1):145-57

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