Liraglutide compromises pancreatic beta cell function in a humanized mouse model
On the web-site of Karolinska Institutet, there is a recent post regarding a new publication of high impact:
“Long-term use of liraglutide, a substance that helps to lower blood sugar levels in patients with type 2 diabetes, can have a deteriorating effect on insulin-producing beta cells, leading to an increase in blood sugar levels. This according to a study on mice implanted with human insulin-producing cells conducted by a team of scientists from Karolinska Institutet, and the University of Miami, USA. The researchers flag the possible consequences of this popular form of therapy in Cell Metabolism.”
3. Liraglutide compromises pancreatic beta cell function in a humanized mouse model. Midhat H. Abdulreda, Rayner Rodriguez-Diaz, Alejandro Caicedo, Per-Olof Berggren. Cell Metabolism 23, 1-6, March 8, 2016, doi.org/10.1016/j.cmet.2016.01.009. Online February 11, 2016.