T Cells behaviors uncovered with InSight Technology featured in JEM on the 24th of February, 2014.
How real-time imaging studies depicted the interaction of self-antigen-specific T cells with target tissue cells in vivo, has been described in an article in JEM, The Journal of Experimental Medicine. The study illustrates tolerance induction by contact-based immune cell interaction in target tissues and highlights potentials of tissue regeneration under antigenic incognito in inflammatory settings.
The findings are important for the understanding of immune cell behavior and for future improvement of therapeutic interventions.