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Home » News » Publication » Proteomic Analysis reveals involvement of the FPR2 pathway in insulin resistance

Proteomic Analysis reveals involvement of the FPR2 pathway in insulin resistance

Proteomic Analysis reveals involvement of the FPR2 pathway in insulin resistance

Elevated levels of the free fatty acid palmitate are found in the plasma of obese patients and induce insulin resistance. In a study presented in the April issue of Molecular & Cellular Proteomics, the skeletal muscle secretome in response to palmitate-induced insulin resistance was identified and characterized. Bioinformatics analysis revealed that palmitate-induced insulin resistance induced cellular stress and modulated secretory events. The findings contribute to the understanding of insulin resistance of skeletal muscle, as well as systemic insulin sensitivity.

Read more:    Proteomic Analysis of the Palmitate-induced Myotube Secretome Reveals Involvement of the Annexin A1-Formyl Peptide Receptor 2 (FPR2) Pathway in Insulin Resistance. Jong Hyuk Yoon, Davea Kim, Jin-Hyeok Jang, Jaewang Ghim, Soyeon Park, Parkyong Song, Yonghoon Kwon, Jaevoon Kim, Daehee Hwang, Yoe-Sik Bae, Pann-Ghill Suh, Per-Olof Berggren, Sung Ho Ryu. April 1, 2015 Molecular & Cellular Proteomics, 14, 882-892.

September 2, 2020 Catharina Rahm

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