Proteomic Analysis reveals involvement of the FPR2 pathway in insulin resistance
Elevated levels of the free fatty acid palmitate are found in the plasma of obese patients and induce insulin resistance. In a study presented in the April issue of Molecular & Cellular Proteomics, the skeletal muscle secretome in response to palmitate-induced insulin resistance was identified and characterized. Bioinformatics analysis revealed that palmitate-induced insulin resistance induced cellular stress and modulated secretory events. The findings contribute to the understanding of insulin resistance of skeletal muscle, as well as systemic insulin sensitivity.