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Home » News » Publication » InSight for observing how immune system reacts to the islets of Langerhans

InSight for observing how immune system reacts to the islets of Langerhans

 

 

 

 

New success of the InSight* technology is now presented in an article in PNAS from July 18th, 2011. Using this unique technology in a mouse model, reactions of the immune system to implanted islets of Langerhans were for the first time observed in a living organism.

Following an allogeneic transplantation of beta cells into the anterior chamber of a mouse eye, immune reactions were studied at the cellular level, using a specifically designed microscopic system. Cell-to-cell interactions and cell signaling pathways were observed in a day-to-day destruction process, as the immune system eliminated the implanted islet of Langerhans.

Importantly, by using the InSight technology, it was also possible to demonstrate how to interfere with the immune attack.

* In the publication, the name InSight has not been used.

Read more:

High-resolution, noninvasive longitudinal live imaging of immune responses. Abdulreda MH et.al. PNAS, June 2011

February 21, 2012 Catharina Rahm

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