Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase. A study presented in the September issue of Cellular Signalling, suggests that apolipoprotein a1 can alleviate obesity related metabolic disease by inducing AMPK dependent mitochondrial biogenesis. Read more:    Apolipoprotein a1 increases mitochondrial biogenesis through AMP-activated protein kinase. Parkyong Song, Yonghoon Kwon, Kyungmoo Yea, Hyo-Youl Moon, …

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation. In this study IR-A48 is presented as a biased agonist able to selectively induce the metabolic activity of insulin receptors through allosteric binding. This is the first study to show that aptamer–protein interactions can not only differentially modulate receptor …

The pancreatic beta-cell in deadly encounter with apolipoprotein CIII A publication in Cell Cycle describes studies which demonstrate that preventing insulin resistance at the islet level is crucial to maintain beta-cell function and survival in diabetes. Tests in a T2DM mouse model were performed using the Biocrine InSight in vivo technology. Targeting the local islet …