Voltage-gated CaV channels as potential targets for anti-diabetes therapy The voltage-gated Ca(2+) (CaV) channel acts as a key player in β cell physiology and pathophysiology. β cell CaV channels undergo hyperactivation subsequent to exposure to type 1 diabetic (T1D) serum resulting in Ca(2+)-triggered β cell apoptosis. In the March 2015 issue of Cellular and Molecular …